Since it was first established in 1919, MUSC Health - Orangeburg has grown from a small private hospital into a robust regional health care system. MUSC Health – Orangeburg’s network now includes a 286-bed acute care hospital in Orangeburg, a breast center with mobile mammography capabilities, Bamberg-Barnwell Emergency Medical Center, Express Care locations in Orangeburg and Santee, seven primary care clinics, and fifteen specialty practices located throughout Orangeburg, Bamburg and Calhoun counties.

Specialty services offered include cardiology, endocrinology, general surgery, urology, behavioral health, neurology, obstetrics and gynecology, internal medicine, orthopaedics, vein and vascular services, and outpatient physical, occupational and speech therapy.